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Profile of Md. Abdur  Razzaque
   

Md. Abdur  Razzaque
 
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Profile created on 30/05/2005

 

M.Sc.: Biochemistry, DU (1996): MS from Himeji Institute of Technology, Japan (2002)

Ph.D.: Himeji Institute of Technology, University of Hyogo, Japan (2005)

Post Doctorate: University of Hyogo from April, 2005

Present Position: Researcher, International Research and Educational Institute for Integrated Medical Sciences(IREIIMS), Tokyo Women`s Medical University

E-mail: mdabdur@yahoo.com, razzaque@imcir.twmu.ac.jp

Website: http://ireiims-twmu.imcir-unet.ocn.ne.jp/

Area of Specialization : Molecular Biology (nuclear receptor signaling in animals)

Achievement : Dr. Abdur Razzaque and his associates at the University of Hyogo (Japan) cloned rat ERRgamma as an interacting partner of an orphan nuclear receptor termed small heterodimer partner (SHP). ERRgamma is a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan (= that lack identified ligands) nuclear receptors. They reported that ERRgamma recognizes a enormously broad range of sequences as a homodimer. Furthermore, their studies reveal that SHP efficiently represses the transcriptional activity of ERRgamma at a concentration far lower than ERRgamma.

Future Plan : In his new position he will be working on congenital heart diseases - mostly screening the mutants and searching for new genes responsible for heart diseases and analyzing their functions both in vitro and in vivo.

Research Interest : Nuclear Receptor Signalling, Transcription Factors and Gene Regulation

Latest Publications :

     Razzaque MA, Masuda N, Maeda Y, Endo Y, Tsukamoto T, Osumi T. (2004)Estrogen receptor-related receptor gamma has an exceptionally broad specificity of DNA sequence recognition. Gene 340(2):275-82.